1YNW
Crystal Structure of Vitamin D Receptor and 9-cis Retinoic Acid Receptor DNA-Binding Domains Bound to a DR3 Response Element
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | C | 5'-d(*TP*TP*AP*GP*GP*TP*CP*AP*CP*GP*AP*AP*GP*GP*TP*CP*AP*A)-3' | polymer | 18 | 5564.6 | 1 | |||
| 2 | D | 5'-d(*TP*TP*TP*GP*AP*CP*CP*TP*TP*CP*GP*TP*GP*AP*CP*CP*TP*A)-3' | polymer | 18 | 5457.5 | 1 | |||
| 3 | A | Vitamin D3 Receptor | polymer | 110 | 12784.1 | 1 | UniProt (P11473) Pfam (PF00105) In PDB | Homo sapiens (human) | VDR; 1,25-dihydroxyvitamin D3 receptor |
| 4 | B | Retinoic acid receptor RXR-alpha | polymer | 99 | 11642.2 | 1 | UniProt (P19793) Pfam (PF00105) In PDB | Homo sapiens (human) | 9-cis Retinoic Acid Receptor; Retinoid X receptor alpha |
| 5 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
A: 16 - 125 (UniProt: P11473)
| PDB | External Database | Details |
|---|---|---|
| Ala 61 | Pro 61 | engineered mutation |
| Ala 62 | Phe 62 | engineered mutation |
| Ala 75 | His 75 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 35448.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 35710.1 |
