1YMM

TCR/HLA-DR2b/MBP-peptide complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class II histocompatibility antigen, DR alpha chain	polymer	191	22107.9	1	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	HLA-DR2b alpha
2	B (B)	HLA class II histocompatibility antigen, DR beta chain	polymer	198	22991.6	1	UniProt (Q29790) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911)	Homo sapiens (human)	HLA-DR2b beta
3	C (C)	MBP peptide	polymer	23	2286.5	1	UniProt (P02686)
4	D (D)	T cell receptor alpha chain	polymer	207	22978.3	1	GenBank (29293741) Pfam (PF09291) UniProt (by SIFTS) (P01848)	Homo sapiens (human)	TCR Ob.1A12 alpha
5	E (E)	T-cell receptor beta chain	polymer	249	27934.1	1	UniProt (P01850) Pfam (PF07654)	Homo sapiens (human)	TCR Ob.1A12 beta
6	F (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

D: 1 - 207 (GenBank: 29293741)

PDB	External Database	Details
Asp 92	Ala 112	see remark 999
Thr 93	Asn 113	see remark 999
Thr 94	Ala 114	see remark 999
Ser 95	Gly 115	see remark 999
-	Ser 118	see remark 999
-	Gly 120	see remark 999
Tyr 100	Leu 122	see remark 999
Ile 101	Thr 123	see remark 999
Thr 104	Gln 126	see remark 999
Arg 107	Ile 129	see remark 999
Lys 109	Thr 131	see remark 999
Leu 111	His 133	see remark 999
Ala 112	Pro 134	see remark 999

E: 1 - 249 (UniProt: P01850)

PDB	External Database	Details
Ser 13	Cys 28	engineered mutation
Asp 98	Glu 113	see remark 999
Leu 99	Ser 114	see remark 999
Gly 102	Asp 117	see remark 999
Ala 103	Pro 118	see remark 999
Asn 104	Lys 119	see remark 999
Ser 193	Cys 208	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	98298.5
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	98519.7

*Water molecules are not included.