1YFZ
Novel IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 205 | 22762.6 | 2 | UniProt (Q8R7L0) Pfam (PF00156) | Thermoanaerobacter tengcongensis | |
| 2 | C, G (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) PubChem (175) | |||
| 3 | D, E, H, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 4 | F, J (A, B) | INOSINIC ACID | non-polymer | 348.2 | 2 | Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 181 (UniProt: Q8R7L0)
| PDB | External Database | Details |
|---|---|---|
| Met -23 | - | cloning artifact |
| Ala -22 | - | cloning artifact |
| Ser -21 | - | cloning artifact |
| Met -20 | - | cloning artifact |
| Thr -19 | - | cloning artifact |
| Gly -18 | - | cloning artifact |
| Gly -17 | - | cloning artifact |
| Gln -16 | - | cloning artifact |
| Gln -15 | - | cloning artifact |
| Met -14 | - | cloning artifact |
| Gly -13 | - | cloning artifact |
| Arg -12 | - | cloning artifact |
| Gly -11 | - | cloning artifact |
| Ser -10 | - | cloning artifact |
| Ser -9 | - | cloning artifact |
| Thr -8 | - | cloning artifact |
| Ser -7 | - | cloning artifact |
| Leu -6 | - | cloning artifact |
| Tyr -5 | - | cloning artifact |
| Lys -4 | - | cloning artifact |
| Lys -3 | - | cloning artifact |
| Ala -2 | - | cloning artifact |
| Gly -1 | - | cloning artifact |
| Leu 0 | - | cloning artifact |
| Gly 53 | Asp 53 | engineered mutation |
| Leu 67 | Met 67 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45525.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 911.7 | |
| All* | Total formula weight | 46436.9 |
