1YFZ
Novel IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 205 | 22762.6 | 2 | UniProt (Q8R7L0) Pfam (PF00156) In PDB | Thermoanaerobacter tengcongensis | |
| 2 | A, B | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | A, B | INOSINIC ACID | non-polymer | 348.2 | 2 | Chemie (IMP) | |||
| 5 | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 181 (UniProt: Q8R7L0)
| PDB | External Database | Details |
|---|---|---|
| Met -23 | - | cloning artifact |
| Ala -22 | - | cloning artifact |
| Ser -21 | - | cloning artifact |
| Met -20 | - | cloning artifact |
| Thr -19 | - | cloning artifact |
| Gly -18 | - | cloning artifact |
| Gly -17 | - | cloning artifact |
| Gln -16 | - | cloning artifact |
| Gln -15 | - | cloning artifact |
| Met -14 | - | cloning artifact |
| Gly -13 | - | cloning artifact |
| Arg -12 | - | cloning artifact |
| Gly -11 | - | cloning artifact |
| Ser -10 | - | cloning artifact |
| Ser -9 | - | cloning artifact |
| Thr -8 | - | cloning artifact |
| Ser -7 | - | cloning artifact |
| Leu -6 | - | cloning artifact |
| Tyr -5 | - | cloning artifact |
| Lys -4 | - | cloning artifact |
| Lys -3 | - | cloning artifact |
| Ala -2 | - | cloning artifact |
| Gly -1 | - | cloning artifact |
| Leu 0 | - | cloning artifact |
| Gly 53 | Asp 53 | engineered mutation |
| Leu 67 | Met 67 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45525.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 911.7 | |
| All* | Total formula weight | 46436.9 |
