1YFZ
Novel IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006178 | biological_process | guanine salvage |
| A | 0006188 | biological_process | IMP biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0043101 | biological_process | purine-containing compound salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006178 | biological_process | guanine salvage |
| B | 0006188 | biological_process | IMP biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0043101 | biological_process | purine-containing compound salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 1200 |
| Chain | Residue |
| A | ILE103 |
| A | ASP105 |
| A | SER106 |
| A | GLY107 |
| A | LEU108 |
| A | THR109 |
| A | LEU110 |
| A | HOH1281 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT B 2200 |
| Chain | Residue |
| B | ASP105 |
| B | SER106 |
| B | GLY107 |
| B | LEU108 |
| B | THR109 |
| B | LEU110 |
| B | HOH2294 |
| B | ILE103 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 2191 |
| Chain | Residue |
| B | GLU101 |
| B | ASP102 |
| B | HOH2273 |
| B | HOH2279 |
| B | HOH2285 |
| B | HOH2288 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 2192 |
| Chain | Residue |
| B | ASP161 |
| B | IMP2210 |
| B | HOH2253 |
| B | HOH2258 |
| B | HOH2278 |
| B | HOH2283 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1191 |
| Chain | Residue |
| A | GLU101 |
| A | ASP102 |
| A | HOH1251 |
| A | HOH1269 |
| A | HOH1270 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1192 |
| Chain | Residue |
| A | ASP161 |
| A | IMP1210 |
| A | HOH1236 |
| A | HOH1257 |
| A | HOH1260 |
| A | HOH1274 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE IMP A 1210 |
| Chain | Residue |
| A | LEU44 |
| A | LYS45 |
| A | GLY46 |
| A | LYS133 |
| A | PHE154 |
| A | VAL155 |
| A | ASP161 |
| A | ARG167 |
| A | MG1192 |
| A | HOH1257 |
| A | HOH1274 |
| A | HOH1283 |
| A | HOH1284 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE IMP B 2210 |
| Chain | Residue |
| B | LYS45 |
| B | GLY46 |
| B | ASP105 |
| B | LYS133 |
| B | PHE154 |
| B | VAL155 |
| B | ASP161 |
| B | ARG167 |
| B | MG2192 |
| B | HOH2250 |
| B | HOH2253 |
| B | HOH2278 |
| B | HOH2283 |
| B | HOH2285 |
| B | HOH2291 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDSGlT |
| Chain | Residue | Details |
| A | VAL97-THR109 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| A | ASP102 | |
| A | LYS133 | |
| A | GLU101 | |
| A | ASP105 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| B | ASP102 | |
| B | LYS133 | |
| B | GLU101 | |
| B | ASP105 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| A | ASP102 | |
| A | LYS133 | |
| A | GLU101 | |
| A | ARG137 | |
| A | ASP105 |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| B | ASP102 | |
| B | LYS133 | |
| B | GLU101 | |
| B | ARG137 | |
| B | ASP105 |
