1YF8

Crystal structure of Himalayan mistletoe RIP reveals the presence of a natural inhibitor and a new functionally active sugar-binding site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Beta-galactoside-specific lectin 4	polymer	240	26566.9	1	UniProt (Q6ITZ3) Pfam (PF00161) In PDB	Viscum album (European mistletoe)	ribosome-inactivating protein, MISTLETOE LECTIN
2	B	Beta-galactoside-specific lectin 4	polymer	255	27633.7	1	UniProt (Q6ITZ3) Pfam (PF00652) In PDB	Viscum album (European mistletoe)	ribosome-inactivating protein, MISTLETOE LECTIN
3	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	D	beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G24199JF)
5	E	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G62182OO)
6	F, G	beta-D-galactopyranose-(1-4)-beta-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900004) GlyTouCan (G84224TW)		beta-lactose
7	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
8	A	2-AMINO-4-ISOPROPYL-PTERIDINE-6-CARBOXYLIC ACID	non-polymer		233.2	1	Chemie (P6C)
9	B	beta-D-galactopyranose	non-polymer		180.2	1	Chemie (GAL)
10		water	water		18.0	107	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	54200.6
Branched	Number of molecules	5
	Total formula weight	2444.2
Non-Polymers*	Number of molecules	3
	Total formula weight	634.6
All*	Total formula weight	57279.4

*Water molecules are not included.