1YA7

Implications for interactions of proteasome with PAN and PA700 from the 1.9 A structure of a proteasome-11S activator complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Proteasome alpha subunit	polymer	233	25829.4	7	UniProt (P25156) Pfam (PF10584) Pfam (PF00227)	Thermoplasma acidophilum	Multicatalytic endopeptidase complex alpha subunit
2	H, I, J, K, L... (H, I, J, K, L...)	Proteasome beta subunit	polymer	217	23998.7	7	UniProt (P28061) Pfam (PF00227)	Thermoplasma acidophilum	Multicatalytic endopeptidase complex beta subunit
3	O, P, Q, R, S... (O, P, Q, R, S...)	proteasome activator protein PA26	polymer	237	26087.6	7	GenBank (5757773) Pfam (PF02252) UniProt (by SIFTS) (Q9U8G2)	Trypanosoma brucei
4	AA, BA, CA, DA, FA... (G, H, I, J, K...)	SULFATE ION	non-polymer		96.1	21	Chemie (SO4)
5	EA, HA, KA, NA, QA... (H, I, J, K, L...)	GLYCEROL	non-polymer		92.1	7	Chemie (GOL)
6	AB, BB, CB, DB, EB... (D, E, F, G, H...)	water	water		18.0	1659	Chemie (HOH)

Sequence modifications

H, I, J, K, L, M, N: -7 - 203 (UniProt: P28061)

PDB	External Database	Details
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag

O, P, Q, R, S, T, U: 2 - 231 (GenBank: 5757773)

PDB	External Database	Details
Met -5	-	initiating methionine
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Val 49	Thr 49	variant

Contents of the asymmetric unit

Polymers	Number of chains	21
	Total formula weight	531410.5
Non-Polymers*	Number of molecules	28
	Total formula weight	2662.0
All*	Total formula weight	534072.4

*Water molecules are not included.