Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1YA7

Implications for interactions of proteasome with PAN and PA700 from the 1.9 A structure of a proteasome-11S activator complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030163	biological_process	protein catabolic process
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030163	biological_process	protein catabolic process
C	0004175	molecular_function	endopeptidase activity
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010498	biological_process	proteasomal protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030163	biological_process	protein catabolic process
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030163	biological_process	protein catabolic process
E	0004175	molecular_function	endopeptidase activity
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010498	biological_process	proteasomal protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030163	biological_process	protein catabolic process
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030163	biological_process	protein catabolic process
G	0004175	molecular_function	endopeptidase activity
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010498	biological_process	proteasomal protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030163	biological_process	protein catabolic process
H	0004175	molecular_function	endopeptidase activity
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0005839	cellular_component	proteasome core complex
H	0010498	biological_process	proteasomal protein catabolic process
H	0019774	cellular_component	proteasome core complex, beta-subunit complex
H	0030163	biological_process	protein catabolic process
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0010498	biological_process	proteasomal protein catabolic process
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0030163	biological_process	protein catabolic process
J	0004175	molecular_function	endopeptidase activity
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0030163	biological_process	protein catabolic process
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0010498	biological_process	proteasomal protein catabolic process
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0030163	biological_process	protein catabolic process
L	0004175	molecular_function	endopeptidase activity
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0005839	cellular_component	proteasome core complex
L	0010498	biological_process	proteasomal protein catabolic process
L	0019774	cellular_component	proteasome core complex, beta-subunit complex
L	0030163	biological_process	protein catabolic process
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0010498	biological_process	proteasomal protein catabolic process
M	0019774	cellular_component	proteasome core complex, beta-subunit complex
M	0030163	biological_process	protein catabolic process
N	0004175	molecular_function	endopeptidase activity
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0005839	cellular_component	proteasome core complex
N	0010498	biological_process	proteasomal protein catabolic process
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0030163	biological_process	protein catabolic process
O	0006508	biological_process	proteolysis
O	0008537	cellular_component	proteasome activator complex
O	0061136	biological_process	regulation of proteasomal protein catabolic process
P	0006508	biological_process	proteolysis
P	0008537	cellular_component	proteasome activator complex
P	0061136	biological_process	regulation of proteasomal protein catabolic process
Q	0006508	biological_process	proteolysis
Q	0008537	cellular_component	proteasome activator complex
Q	0061136	biological_process	regulation of proteasomal protein catabolic process
R	0006508	biological_process	proteolysis
R	0008537	cellular_component	proteasome activator complex
R	0061136	biological_process	regulation of proteasomal protein catabolic process
S	0006508	biological_process	proteolysis
S	0008537	cellular_component	proteasome activator complex
S	0061136	biological_process	regulation of proteasomal protein catabolic process
T	0006508	biological_process	proteolysis
T	0008537	cellular_component	proteasome activator complex
T	0061136	biological_process	regulation of proteasomal protein catabolic process
U	0006508	biological_process	proteolysis
U	0008537	cellular_component	proteasome activator complex
U	0061136	biological_process	regulation of proteasomal protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 3001

Chain	Residue
A	GLU110
A	LYS114
B	SER63
B	ILE64
B	GLU65
B	GLN68
B	HOH3061
H	ARG71
H	HOH3091

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 3002

Chain	Residue
B	GLU110
B	LYS114
C	ILE64
C	GLU65
C	GLN68
C	HOH3063
I	ARG71

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 3003

Chain	Residue
C	GLU110
C	LYS114
D	SER63
D	ILE64
D	GLU65
D	GLN68
J	ARG71

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 3004

Chain	Residue
D	GLU110
D	LYS114
E	SER63
E	GLU65
E	GLN68
K	ARG71

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 3005

Chain	Residue
E	GLU110
E	LYS114
F	SER63
F	ILE64
F	GLU65
F	GLN68
L	ARG71

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 G 3006

Chain	Residue
F	GLU110
F	LYS114
G	SER63
G	ILE64
G	GLU65
G	GLN68
M	ARG71

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 G 3007

Chain	Residue
A	SER63
A	GLU65
A	GLN68
G	GLU110
G	LYS114
G	HOH3062
N	ARG71

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 3008

Chain	Residue
H	THR1
H	GLY47
H	GLY128
H	SER129
H	HOH3045
H	HOH3067

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 N 3009

Chain	Residue
N	THR1
N	GLY47
N	GLY128
N	SER129
N	HOH3073
N	HOH3080

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 M 3010

Chain	Residue
M	THR1
M	GLY47
M	GLY128
M	SER129

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 I 3011

Chain	Residue
I	THR1
I	GLY47
I	GLY128
I	SER129

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 J 3012

Chain	Residue
J	THR1
J	GLY47
J	GLY128
J	SER129
J	HOH3092

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 K 3013

Chain	Residue
K	THR1
K	GLY47
K	GLY128
K	SER129
K	HOH3039
K	HOH3063
K	HOH3075

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 L 3014

Chain	Residue
L	THR1
L	GLY47
L	GLY128
L	SER129
L	HOH3038
L	HOH3082
L	HOH3094

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 3015

Chain	Residue
A	TYR103
A	ARG115
H	ARG70
H	HOH3025
H	HOH3061
H	HOH3109

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 I 3016

Chain	Residue
I	HOH3033
I	HOH3078
B	TYR103
B	ARG115
I	ARG70
I	HOH3025

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 J 3017

Chain	Residue
C	TYR103
C	ARG115
J	GLN69
J	ARG70
J	HOH3038
J	HOH3041
J	HOH3078

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 K 3018

Chain	Residue
D	TYR103
D	ARG115
K	ARG70
K	HOH3028
K	HOH3052
K	HOH3079

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 3019

Chain	Residue
E	TYR103
E	ARG115
L	ARG70
L	HOH3062
L	HOH3105

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 M 3020

Chain	Residue
F	TYR103
F	ARG115
M	ARG70
M	HOH3049
M	HOH3105
M	HOH3116

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 N 3021

Chain	Residue
G	TYR103
G	ARG115
N	ARG70
N	HOH3034
N	HOH3049
N	HOH3060

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL L 2001

Chain	Residue
L	GLN53
L	ARG57
L	LYS60

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL M 2002

Chain	Residue
M	GLN53
M	ARG57
M	LYS60
M	HOH3042
M	HOH3106

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL N 2003

Chain	Residue
N	ARG57
N	LYS60
N	HOH3101

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL H 2004

Chain	Residue
H	ARG57
H	LYS60
H	HOH3086
I	HOH3073

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL I 2005

Chain	Residue
I	GLN53
I	VAL56
I	ARG57
I	LYS60
I	HOH3072

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL J 2006

Chain	Residue
J	GLN53
J	VAL56
J	ARG57
J	LYS60
J	HOH3063

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL K 2007

Chain	Residue
K	GLN53
K	VAL56
K	ARG57
K	LYS60
K	HOH3065
K	HOH3066

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGRlfQVEYAreA

Chain	Residue	Details
A	TYR8-ALA30

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGItLkdAVIMATErrvtmenfimhkngk.KlfqidtytgmtiaGlvGD

Chain	Residue	Details
H	VAL4-ASP51

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_02113","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7725107","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
H	GLY47
H	LYS33
H	THR1
H	SER129

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
C	GLY80
C	SER35
C	SER167
C	LYS66

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
D	GLY80
D	SER35
D	SER167
D	LYS66

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
E	GLY80
E	SER35
E	SER167
E	LYS66

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
F	GLY80
F	SER35
F	SER167
F	LYS66

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
G	GLY80
G	SER35
G	SER167
G	LYS66

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
I	GLY47
I	LYS33
I	THR1
I	SER129

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
J	GLY47
J	LYS33
J	THR1
J	SER129

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
K	GLY47
K	LYS33
K	THR1
K	SER129

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
L	GLY47
L	LYS33
L	THR1
L	SER129

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
M	GLY47
M	LYS33
M	THR1
M	SER129

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
N	GLY47
N	LYS33
N	THR1
N	SER129

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
A	GLY80
A	SER35
A	SER167
A	LYS66

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
B	GLY80
B	SER35
B	SER167
B	LYS66

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)