1Y6K
Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Interleukin-10 | polymer | 160 | 18672.4 | 1 | UniProt (P22301) Pfam (PF00726) | Homo sapiens (human) | IL-10, Cytokine synthesis inhibitory factor, CSIF |
| 2 | B (R) | Interleukin-10 receptor alpha chain | polymer | 214 | 24506.6 | 1 | UniProt (Q13651) Pfam (PF01108) | Homo sapiens (human) | IL-10R-A, IL-10R1 |
| 3 | C, D (L, R) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
R: 1 - 214 (UniProt: Q13651)
| PDB | External Database | Details |
|---|---|---|
| Gln 29 | Asn 50 | engineered mutation |
| Gln 53 | Asn 74 | engineered mutation |
| Gln 89 | Asn 110 | engineered mutation |
| Gln 133 | Asn 154 | engineered mutation |
| Gln 156 | Asn 177 | engineered mutation |
| Gln 168 | Asn 189 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43179.0 | |
| All* | Total formula weight | 43179.0 |
