1Y6K

Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0001817	biological_process	regulation of cytokine production
L	0001818	biological_process	negative regulation of cytokine production
L	0001819	biological_process	positive regulation of cytokine production
L	0001938	biological_process	positive regulation of endothelial cell proliferation
L	0002237	biological_process	response to molecule of bacterial origin
L	0002439	biological_process	chronic inflammatory response to antigenic stimulus
L	0002639	biological_process	positive regulation of immunoglobulin production
L	0002719	biological_process	negative regulation of cytokine production involved in immune response
L	0002875	biological_process	negative regulation of chronic inflammatory response to antigenic stimulus
L	0002904	biological_process	positive regulation of B cell apoptotic process
L	0005125	molecular_function	cytokine activity
L	0005141	molecular_function	interleukin-10 receptor binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0006955	biological_process	immune response
L	0007253	biological_process	cytoplasmic sequestering of NF-kappaB
L	0008083	molecular_function	growth factor activity
L	0008285	biological_process	negative regulation of cell population proliferation
L	0009410	biological_process	response to xenobiotic stimulus
L	0010033	biological_process	response to organic substance
L	0010468	biological_process	regulation of gene expression
L	0010507	biological_process	negative regulation of autophagy
L	0014823	biological_process	response to activity
L	0014854	biological_process	response to inactivity
L	0030097	biological_process	hemopoiesis
L	0030183	biological_process	B cell differentiation
L	0030595	biological_process	leukocyte chemotaxis
L	0030886	biological_process	negative regulation of myeloid dendritic cell activation
L	0030889	biological_process	negative regulation of B cell proliferation
L	0032496	biological_process	response to lipopolysaccharide
L	0032687	biological_process	negative regulation of interferon-alpha production
L	0032689	biological_process	negative regulation of type II interferon production
L	0032692	biological_process	negative regulation of interleukin-1 production
L	0032695	biological_process	negative regulation of interleukin-12 production
L	0032701	biological_process	negative regulation of interleukin-18 production
L	0032715	biological_process	negative regulation of interleukin-6 production
L	0032717	biological_process	negative regulation of interleukin-8 production
L	0032720	biological_process	negative regulation of tumor necrosis factor production
L	0032868	biological_process	response to insulin
L	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
L	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
L	0034465	biological_process	response to carbon monoxide
L	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
L	0042092	biological_process	type 2 immune response
L	0042100	biological_process	B cell proliferation
L	0042130	biological_process	negative regulation of T cell proliferation
L	0042742	biological_process	defense response to bacterium
L	0042832	biological_process	defense response to protozoan
L	0043032	biological_process	positive regulation of macrophage activation
L	0043066	biological_process	negative regulation of apoptotic process
L	0043524	biological_process	negative regulation of neuron apoptotic process
L	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
L	0045191	biological_process	regulation of isotype switching
L	0045347	biological_process	negative regulation of MHC class II biosynthetic process
L	0045348	biological_process	positive regulation of MHC class II biosynthetic process
L	0045787	biological_process	positive regulation of cell cycle
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045930	biological_process	negative regulation of mitotic cell cycle
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
L	0046983	molecular_function	protein dimerization activity
L	0050728	biological_process	negative regulation of inflammatory response
L	0050807	biological_process	regulation of synapse organization
L	0051045	biological_process	negative regulation of membrane protein ectodomain proteolysis
L	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
L	0051384	biological_process	response to glucocorticoid
L	0060302	biological_process	negative regulation of cytokine activity
L	0060670	biological_process	branching involved in labyrinthine layer morphogenesis
L	0071222	biological_process	cellular response to lipopolysaccharide
L	0071392	biological_process	cellular response to estradiol stimulus
L	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
L	0072577	biological_process	endothelial cell apoptotic process
L	0097421	biological_process	liver regeneration
L	0140105	biological_process	interleukin-10-mediated signaling pathway
L	1900100	biological_process	positive regulation of plasma cell differentiation
L	1902895	biological_process	positive regulation of miRNA transcription
L	1903034	biological_process	regulation of response to wounding
L	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
L	1903659	biological_process	regulation of complement-dependent cytotoxicity
L	1903672	biological_process	positive regulation of sprouting angiogenesis
L	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
L	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
L	2000273	biological_process	positive regulation of signaling receptor activity
L	2000352	biological_process	negative regulation of endothelial cell apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS00520
Number of Residues	21
Details	INTERLEUKIN_10 Interleukin-10 family signature. KgylgCQalseMIqFYLeEVM

Chain	Residue	Details
L	LYS57-MET77

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	213
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
R	HIS1-ASN214

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site_id	SWS_FT_FI2
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
R	GLN29
R	GLN53
R	GLN89
R	GLN133
R	GLN156
R	GLN168

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