1Y5M
The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Corticosteroid 11-beta-dehydrogenase, isozyme 1 | polymer | 276 | 30585.7 | 2 | UniProt (P50172) Pfam (PF00106) | Mus musculus (house mouse) | 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1, 11beta-HSD1A |
| 2 | C, D, G, H (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | E, I (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | F, J (A, B) | N-OCTANE | non-polymer | 114.2 | 2 | Chemie (OCT) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 292 (UniProt: P50172)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61171.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2103.6 | |
| All* | Total formula weight | 63274.9 |
