1Y2D

Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-methoxy-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	349	40096.4	2	UniProt (Q08499) Pfam (PF00233)	Homo sapiens (human)	DPDE3, PDE43
2	C, R (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, S (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E, T (A, B)	1-(4-METHOXYPHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER	non-polymer		274.3	2	Chemie (4DE)
5	AA, BA, CA, DA, EA... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	24	Chemie (EDO)
6	GA (B)	2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		282.3	1	Chemie (B3P)
7	HA, IA (A, B)	water	water		18.0	540	Chemie (HOH)

Sequence modifications

A, B: 86 - 413 (UniProt: Q08499)

PDB	External Database	Details
Met 65	-	initiating methionine
Gly 66	-	cloning artifact
Ser 67	-	cloning artifact
Ser 68	-	cloning artifact
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
His 74	-	expression tag
Ser 75	-	cloning artifact
Ser 76	-	cloning artifact
Gly 77	-	cloning artifact
Leu 78	-	cloning artifact
Val 79	-	cloning artifact
Pro 80	-	cloning artifact
Arg 81	-	cloning artifact
Gly 82	-	cloning artifact
Ser 83	-	cloning artifact
His 84	-	cloning artifact
Met 85	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80192.7
Non-Polymers*	Number of molecules	31
	Total formula weight	2500.0
All*	Total formula weight	82692.7

*Water molecules are not included.