Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | HIS164 |
| A | HIS200 |
| A | ASP201 |
| A | ASP318 |
| A | HOH1007 |
| A | HOH1008 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | HOH1005 |
| A | HOH1006 |
| A | HOH1007 |
| A | ASP201 |
| A | HOH1003 |
| A | HOH1004 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 1001 |
| Chain | Residue |
| B | HIS164 |
| B | HIS200 |
| B | ASP201 |
| B | ASP318 |
| B | MG1002 |
| B | HOH2007 |
| B | HOH2008 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 1002 |
| Chain | Residue |
| B | ASP201 |
| B | ZN1001 |
| B | HOH2003 |
| B | HOH2004 |
| B | HOH2005 |
| B | HOH2006 |
| B | HOH2007 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 4DE A 601 |
| Chain | Residue |
| A | MET273 |
| A | THR333 |
| A | MET357 |
| A | GLN369 |
| A | PHE372 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 4DE B 602 |
| Chain | Residue |
| B | ASN321 |
| B | THR333 |
| B | ILE336 |
| B | MET357 |
| B | GLN369 |
| B | PHE372 |
| B | HOH2266 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 701 |
| Chain | Residue |
| A | PRO411 |
| B | GLU366 |
| B | TYR406 |
| B | HOH2068 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 702 |
| Chain | Residue |
| A | LYS262 |
| A | ILE265 |
| A | ASP266 |
| A | HOH1020 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 703 |
| Chain | Residue |
| A | ASN209 |
| A | GLN210 |
| A | HOH1012 |
| A | HOH1025 |
| A | HOH1028 |
| A | HOH1049 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 704 |
| Chain | Residue |
| B | SER208 |
| B | PRO356 |
| B | HOH2183 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 705 |
| Chain | Residue |
| A | PRO179 |
| A | GLY296 |
| A | HIS389 |
| A | ASP391 |
| A | HOH1228 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 706 |
| Chain | Residue |
| A | ASN115 |
| A | ALA155 |
| A | ASN161 |
| A | ASN162 |
| A | ARG335 |
| A | HOH1219 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 707 |
| Chain | Residue |
| A | LEU175 |
| A | THR178 |
| A | TRP384 |
| A | VAL388 |
| A | ASP391 |
| A | ALA392 |
| A | HOH1147 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 708 |
| Chain | Residue |
| B | PHE238 |
| B | ARG257 |
| B | ARG261 |
| B | HOH2081 |
| B | HOH2098 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 709 |
| Chain | Residue |
| A | PHE238 |
| A | ARG257 |
| A | HOH1047 |
| A | HOH1100 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 710 |
| Chain | Residue |
| A | SER208 |
| A | PHE340 |
| A | PRO356 |
| A | HOH1064 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 711 |
| Chain | Residue |
| A | GLY371 |
| A | PHE372 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 712 |
| Chain | Residue |
| B | LYS262 |
| B | ILE265 |
| B | ASP266 |
| B | HOH2039 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 713 |
| Chain | Residue |
| B | HOH2180 |
| B | GLU150 |
| B | ASP151 |
| B | TYR153 |
| B | ASN162 |
| B | EDO718 |
| B | HOH2011 |
| B | HOH2074 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 714 |
| Chain | Residue |
| B | ASP401 |
| B | ASN402 |
| B | HOH2012 |
| B | HOH2108 |
| B | HOH2181 |
| site_id | CC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 715 |
| Chain | Residue |
| B | ASP156 |
| B | VAL157 |
| B | ALA158 |
| B | GLU339 |
| B | ARG342 |
| B | HOH2025 |
| B | HOH2060 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 716 |
| Chain | Residue |
| A | ILE213 |
| A | ASN216 |
| A | SER217 |
| A | ALA220 |
| A | LEU221 |
| A | ASP225 |
| B | ARG261 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 717 |
| Chain | Residue |
| A | HIS154 |
| A | ASP203 |
| A | PRO205 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 718 |
| Chain | Residue |
| B | ASN115 |
| B | ALA155 |
| B | ASN162 |
| B | EDO713 |
| B | HOH2074 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 719 |
| Chain | Residue |
| A | GLU366 |
| A | HOH1081 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 720 |
| Chain | Residue |
| A | ALA183 |
| A | VAL184 |
| B | ASN115 |
| B | ARG116 |
| B | HOH2180 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 721 |
| Chain | Residue |
| A | HOH1079 |
| B | GLN327 |
| B | HOH2118 |
| B | HOH2215 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 722 |
| Chain | Residue |
| A | ARG330 |
| B | HOH2012 |
| B | HOH2091 |
| B | HOH2236 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 723 |
| Chain | Residue |
| B | THR178 |
| B | TRP384 |
| B | ASP391 |
| B | EDO724 |
| B | HOH2190 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 724 |
| Chain | Residue |
| B | ASP394 |
| B | EDO723 |
| B | HOH2126 |
| B | HOH2142 |
| B | HOH2256 |
| site_id | DC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE B3P B 801 |
| Chain | Residue |
| A | ASP397 |
| A | ASP401 |
| A | HOH1132 |
| B | LYS94 |
| B | GLU95 |
| B | GLU97 |
| B | ASP98 |
| B | HIS105 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS200-PHE211 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 | |
| Chain | Residue | Details |
| A | HIS160 | |
| A | ASN321 | |
| A | GLN369 | |
| B | HIS160 | |
| B | ASN321 | |
| B | GLN369 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS164 | |
| B | HIS164 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS200 | |
| A | ASP318 | |
| B | HIS200 | |
| B | ASP318 | |
| Chain | Residue | Details |
| A | ASP201 | |
| A | PHE372 | |
| B | ASP201 | |
| B | PHE372 | |
