1XXD
Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Coagulation factor XI | polymer | 238 | 26826.5 | 2 | UniProt (P03951) Pfam (PF00089) | Homo sapiens (human) | Plasma thromboplastin antecedent; PTA; FXI |
| 2 | C, D (C, D) | Ecotin | polymer | 142 | 16235.5 | 2 | UniProt (P23827) Pfam (PF03974) | Escherichia coli | |
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 245 (UniProt: P03951)
C, D: 1 - 142 (UniProt: P23827)
| PDB | External Database | Details |
|---|---|---|
| Ala 56 | Ser 452 | engineered mutation |
| Ala 97 | Thr 493 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 80 | Pro 100 | engineered mutation |
| Asp 81 | Val 101 | engineered mutation |
| Phe 82 | Ser 102 | engineered mutation |
| Arg 84 | Met 104 | engineered mutation |
| Val 85 | Met 105 | engineered mutation |
| Val 86 | Ala 106 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 86124.1 | |
| All* | Total formula weight | 86124.1 |
