1XU7
Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Corticosteroid 11-beta-dehydrogenase, isozyme 1 | polymer | 286 | 31836.9 | 4 | UniProt (P28845) Pfam (PF00106) In PDB | Homo sapiens (human) | 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1 |
2 | A, B, C, D | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
3 | A, B, C, D | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 6 | Chemie (CPS) | |||
4 | water | water | 18.0 | 486 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 292 (UniProt: P28845)
PDB | External Database | Details |
---|---|---|
Met 7 | - | initiating methionine |
Lys 8 | - | cloning artifact |
His 9 | - | cloning artifact |
Gln 10 | - | cloning artifact |
His 11 | - | cloning artifact |
Gln 12 | - | cloning artifact |
His 13 | - | cloning artifact |
Gln 14 | - | cloning artifact |
His 15 | - | cloning artifact |
Gln 16 | - | cloning artifact |
His 17 | - | cloning artifact |
Gln 18 | - | cloning artifact |
His 19 | - | cloning artifact |
Gln 20 | - | cloning artifact |
Gln 21 | - | cloning artifact |
Pro 22 | - | cloning artifact |
Leu 23 | - | cloning artifact |
Ser 272 | Cys 272 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 127347.5 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 6670.9 | |
All* | Total formula weight | 134018.4 |