1XOS
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 398 | 45883.6 | 1 | UniProt (Q07343) Pfam (PF00233) In PDB | Homo sapiens (human) | DPDE4, PDE32 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
5 | A | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | non-polymer | 474.6 | 1 | Chemie (VIA) | |||
6 | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 152 - 528 (UniProt: Q07343)
PDB | External Database | Details |
---|---|---|
Met 131 | - | INITIATING METHIONINE |
Gly 132 | - | CLONING ARTIFACT |
Ser 133 | - | CLONING ARTIFACT |
Ser 134 | - | CLONING ARTIFACT |
His 135 | - | EXPRESSION TAG |
His 136 | - | EXPRESSION TAG |
His 137 | - | EXPRESSION TAG |
His 138 | - | EXPRESSION TAG |
His 139 | - | EXPRESSION TAG |
His 140 | - | EXPRESSION TAG |
Ser 141 | - | CLONING ARTIFACT |
Ser 142 | - | CLONING ARTIFACT |
Gly 143 | - | CLONING ARTIFACT |
Leu 144 | - | CLONING ARTIFACT |
Val 145 | - | CLONING ARTIFACT |
Pro 146 | - | CLONING ARTIFACT |
Arg 147 | - | CLONING ARTIFACT |
Gly 148 | - | CLONING ARTIFACT |
Ser 149 | - | CLONING ARTIFACT |
His 150 | - | CLONING ARTIFACT |
Met 151 | - | CLONING ARTIFACT |
Cme 194 | Cys 366 | MODIFIED RESIDUE |
Cme 320 | Cys 492 | MODIFIED RESIDUE |
Cme 432 | Cys 604 | MODIFIED RESIDUE |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45883.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 660.4 | |
All* | Total formula weight | 46543.9 |