1XOS
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 398 | 45883.6 | 1 | UniProt (Q07343) Pfam (PF00233) | Homo sapiens (human) | DPDE4, PDE32 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E (A) | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | non-polymer | 474.6 | 1 | Chemie (VIA) | |||
| 6 | F (A) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 152 - 528 (UniProt: Q07343)
| PDB | External Database | Details |
|---|---|---|
| Met 131 | - | initiating methionine |
| Gly 132 | - | cloning artifact |
| Ser 133 | - | cloning artifact |
| Ser 134 | - | cloning artifact |
| His 135 | - | expression tag |
| His 136 | - | expression tag |
| His 137 | - | expression tag |
| His 138 | - | expression tag |
| His 139 | - | expression tag |
| His 140 | - | expression tag |
| Ser 141 | - | cloning artifact |
| Ser 142 | - | cloning artifact |
| Gly 143 | - | cloning artifact |
| Leu 144 | - | cloning artifact |
| Val 145 | - | cloning artifact |
| Pro 146 | - | cloning artifact |
| Arg 147 | - | cloning artifact |
| Gly 148 | - | cloning artifact |
| Ser 149 | - | cloning artifact |
| His 150 | - | cloning artifact |
| Met 151 | - | cloning artifact |
| Cme 194 | Cys 366 | modified residue |
| Cme 320 | Cys 492 | modified residue |
| Cme 432 | Cys 604 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45883.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 660.4 | |
| All* | Total formula weight | 46543.9 |
