1XOS

Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	HIS238
A	HIS274
A	ASP275
A	ASP392
A	HOH1007
A	HOH1008

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1002

Chain	Residue
A	HOH1005
A	HOH1006
A	HOH1007
A	ASP275
A	HOH1003
A	HOH1004

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	SER282
A	ASN283
A	GLN284

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE VIA A 1

Chain	Residue
A	HOH10
A	TYR233
A	HIS234
A	MET347
A	ASP392
A	ASN395
A	ILE410
A	MET411
A	SER429
A	MET431
A	CME432
A	GLN443
A	PHE446
A	ILE450
A	HOH1008
A	HOH1009

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS274-PHE285

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15685167","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17727341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18539455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RO6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QYL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10846163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15685167","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17727341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18539455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F0J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QYL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10846163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15685167","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18539455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F0J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---