1XON

Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	349	40096.4	2	UniProt (Q08499) Pfam (PF00233)	Homo sapiens (human)	DPDE3, PDE43
2	AA, C (B, A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	BA, D (B, A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	CA, E (B, A)	3-(CYCLOPENTYLOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-METHOXYBENZAMIDE	non-polymer		381.3	2	Chemie (PIL)
5	F (A)	2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		282.3	1	Chemie (B3P)
6	DA, EA, FA, G, GA... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	35	Chemie (EDO)
7	SA, TA (A, B)	water	water		18.0	415	Chemie (HOH)

Sequence modifications

A, B: 86 - 413 (UniProt: Q08499)

PDB	External Database	Details
Met 65	-	initiating methionine
Gly 66	-	cloning artifact
Ser 67	-	cloning artifact
Ser 68	-	cloning artifact
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
His 74	-	expression tag
Ser 75	-	cloning artifact
Ser 76	-	cloning artifact
Gly 77	-	cloning artifact
Leu 78	-	cloning artifact
Val 79	-	cloning artifact
Pro 80	-	cloning artifact
Arg 81	-	cloning artifact
Gly 82	-	cloning artifact
Ser 83	-	cloning artifact
His 84	-	cloning artifact
Met 85	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80192.7
Non-Polymers*	Number of molecules	42
	Total formula weight	3396.6
All*	Total formula weight	83589.4

*Water molecules are not included.