Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
A | 0007165 | biological_process | signal transduction |
A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
B | 0007165 | biological_process | signal transduction |
B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ZN A 1001 |
Chain | Residue |
A | HIS164 |
A | HIS200 |
A | ASP201 |
A | ASP318 |
A | HOH1007 |
A | HOH1008 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 1002 |
Chain | Residue |
A | HOH1005 |
A | HOH1006 |
A | HOH1007 |
A | ASP201 |
A | HOH1003 |
A | HOH1004 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ZN B 1001 |
Chain | Residue |
B | HIS164 |
B | HIS200 |
B | ASP201 |
B | ASP318 |
B | HOH2007 |
B | HOH2008 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 1002 |
Chain | Residue |
B | ASP201 |
B | HOH2003 |
B | HOH2004 |
B | HOH2005 |
B | HOH2006 |
B | HOH2007 |
site_id | AC5 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE PIL A 501 |
Chain | Residue |
A | THR271 |
A | MET273 |
A | ASP318 |
A | LEU319 |
A | ASN321 |
A | THR333 |
A | ILE336 |
A | PHE340 |
A | MET357 |
A | GLN369 |
A | PHE372 |
A | EDO744 |
A | HOH1005 |
A | HOH1010 |
site_id | AC6 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PIL B 502 |
Chain | Residue |
B | TYR159 |
B | THR271 |
B | MET273 |
B | ASP318 |
B | LEU319 |
B | ASN321 |
B | THR333 |
B | ILE336 |
B | PHE340 |
B | MET357 |
B | GLN369 |
B | PHE372 |
B | HOH2005 |
B | HOH2010 |
B | HOH2104 |
site_id | AC7 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE B3P A 601 |
Chain | Residue |
A | LYS94 |
A | GLU95 |
A | GLU97 |
A | ASP98 |
A | HIS105 |
A | ARG108 |
A | HOH1165 |
A | HOH1215 |
B | ASP394 |
B | ASP397 |
B | ASP401 |
B | HOH2079 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 701 |
Chain | Residue |
B | GLU366 |
B | HOH2057 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 702 |
Chain | Residue |
A | LYS262 |
A | ILE265 |
A | ASP266 |
A | HOH1037 |
B | ASN224 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 704 |
Chain | Residue |
A | GLN210 |
A | HOH1025 |
A | HOH1038 |
A | HOH1041 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO B 706 |
Chain | Residue |
B | ASP98 |
B | GLY103 |
B | HIS105 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 707 |
Chain | Residue |
A | ASN115 |
A | ARG116 |
A | HOH1123 |
A | HOH1124 |
B | ALA183 |
B | VAL184 |
B | HOH2165 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 742 |
Chain | Residue |
A | ASP151 |
B | THR186 |
B | ARG306 |
B | EDO743 |
B | HOH2043 |
B | HOH2107 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 708 |
Chain | Residue |
B | SER208 |
B | PHE340 |
B | PRO356 |
B | HOH2203 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO B 709 |
Chain | Residue |
B | ASN302 |
B | TYR303 |
B | EDO743 |
site_id | BC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 743 |
Chain | Residue |
A | EDO742 |
B | EDO709 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 712 |
Chain | Residue |
A | PRO179 |
A | ALA180 |
A | HIS389 |
A | ASP391 |
B | ARG350 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 715 |
Chain | Residue |
A | ASN115 |
A | ALA155 |
A | ASN162 |
A | ILE163 |
A | HOH1086 |
site_id | CC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 716 |
Chain | Residue |
A | THR178 |
A | TRP384 |
A | ASP391 |
A | ALA392 |
A | ILE395 |
A | HOH1114 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 717 |
Chain | Residue |
B | PHE238 |
B | ARG257 |
B | EDO718 |
B | HOH2040 |
B | HOH2148 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 718 |
Chain | Residue |
A | HOH1202 |
B | ARG257 |
B | GLN258 |
B | ARG261 |
B | EDO717 |
site_id | CC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 719 |
Chain | Residue |
A | VAL184 |
A | LEU298 |
A | LEU299 |
A | LEU300 |
A | ARG306 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 720 |
Chain | Residue |
A | PHE238 |
A | ARG257 |
A | ARG261 |
A | HOH1138 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 722 |
Chain | Residue |
A | SER208 |
A | PHE340 |
A | PRO356 |
A | HOH1106 |
A | HOH1216 |
site_id | CC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 745 |
Chain | Residue |
A | ASP156 |
A | VAL157 |
A | ALA158 |
A | GLU339 |
A | ARG342 |
A | HOH1040 |
A | HOH1161 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 744 |
Chain | Residue |
A | MET273 |
A | PHE372 |
A | ILE376 |
A | PIL501 |
A | EDO723 |
A | HOH1095 |
site_id | CC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 723 |
Chain | Residue |
A | ILE376 |
A | EDO744 |
A | HOH1145 |
site_id | DC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 724 |
Chain | Residue |
A | MET222 |
A | HOH1020 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 725 |
Chain | Residue |
B | LYS262 |
B | ILE265 |
B | ASP266 |
B | HOH2022 |
site_id | DC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 726 |
Chain | Residue |
A | GLN407 |
B | GLU150 |
B | ASP151 |
B | TYR153 |
B | ALA155 |
B | ASN162 |
B | HOH2115 |
site_id | DC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 727 |
Chain | Residue |
A | GLN327 |
A | HOH1081 |
B | TRP405 |
B | EDO728 |
B | HOH2093 |
site_id | DC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 728 |
Chain | Residue |
B | PRO325 |
B | LEU326 |
B | ASP401 |
B | ASN402 |
B | EDO727 |
site_id | DC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 729 |
Chain | Residue |
A | ASP151 |
A | HIS152 |
A | TYR153 |
A | HOH1015 |
B | ASP301 |
B | HOH2024 |
B | HOH2107 |
site_id | DC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 730 |
Chain | Residue |
B | ASP156 |
B | VAL157 |
B | ALA158 |
B | GLU339 |
B | ARG342 |
B | HOH2030 |
B | HOH2039 |
site_id | DC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 731 |
Chain | Residue |
A | GLY371 |
A | ASP374 |
A | TYR375 |
A | HOH1116 |
B | ASP151 |
B | HIS152 |
site_id | DC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 732 |
Chain | Residue |
A | ILE213 |
A | ASN216 |
A | SER217 |
A | ALA220 |
A | LEU221 |
A | ASP225 |
A | HOH1202 |
B | ARG261 |
site_id | EC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 733 |
Chain | Residue |
A | HIS154 |
A | ASP203 |
A | LEU219 |
site_id | EC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 734 |
Chain | Residue |
B | ASN115 |
B | ALA155 |
B | ASN162 |
B | ILE163 |
site_id | EC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 736 |
Chain | Residue |
A | GLU338 |
A | PHE341 |
A | ASP345 |
site_id | EC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 739 |
Chain | Residue |
A | GLN327 |
A | ARG330 |
A | GLN331 |
A | HOH1155 |
B | HOH2054 |
site_id | EC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 740 |
Chain | Residue |
B | LYS367 |
B | VAL370 |
B | GLN407 |
B | ILE410 |
B | HOH2074 |
site_id | EC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 741 |
Chain | Residue |
B | GLN210 |
B | HOH2015 |
B | HOH2033 |
B | HOH2034 |
B | HOH2070 |
Functional Information from PROSITE/UniProt
site_id | PS00126 |
Number of Residues | 12 |
Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
Chain | Residue | Details |
A | HIS200-PHE211 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | HIS160 | |
B | HIS160 | |
Chain | Residue | Details |
A | HIS160 | |
A | ASN321 | |
A | GLN369 | |
B | HIS160 | |
B | ASN321 | |
B | GLN369 | |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
Chain | Residue | Details |
A | HIS164 | |
B | HIS164 | |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
Chain | Residue | Details |
A | HIS200 | |
A | ASP318 | |
B | HIS200 | |
B | ASP318 | |
Chain | Residue | Details |
A | ASP201 | |
A | PHE372 | |
B | ASP201 | |
B | PHE372 | |