1XF9
Structure of NBD1 from murine CFTR- F508S mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cystic fibrosis transmembrane conductance regulator | polymer | 283 | 31708.9 | 4 | UniProt (P26361) Pfam (PF00005) | Mus musculus (house mouse) | CFTR, cAMP-dependent chloride channel |
| 2 | E, I, J, M, N... (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) | |||
| 3 | F, K, O, S (A, B, C, D) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 4 | G, H, L, P, T... (A, B, C, D) | ACETIC ACID | non-polymer | 60.1 | 6 | Chemie (ACY) | |||
| 5 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 388 - 670 (UniProt: P26361)
| PDB | External Database | Details |
|---|---|---|
| Ser 388 | Met 388 | cloning artifact |
| Ser 508 | Phe 508 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 126835.7 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2559.2 | |
| All* | Total formula weight | 129394.9 |
