1X9D
Crystal Structure Of Human Class I alpha-1,2-Mannosidase In Complex With Thio-Disaccharide Substrate Analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase | polymer | 538 | 61429.5 | 1 | UniProt (Q9UKM7) Pfam (PF01532) In PDB | Homo sapiens (human) | ER alpha-1,2-mannosidase, Mannosidase alpha class 1B member 1, Man9GlcNAc2-specific processing alpha-mannosidase, UNQ747/PRO1477 |
| 2 | B | alpha-D-mannopyranose-(1-2)-methyl 2-thio-alpha-D-mannopyranoside | branched | 372.4 | 1 | In PDB BIRD (PRD_900033) GlyTouCan (G32183TR) | methyl 2-S-alpha-D-mannopyranosyl-2-thio-alpha-D-mannopyranoside | ||
| 3 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | A | 1,4-BUTANEDIOL | non-polymer | 90.1 | 1 | Chemie (BU1) | |||
| 6 | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
A: 172 - 699 (UniProt: Q9UKM7)
| PDB | External Database | Details |
|---|---|---|
| Glu 162 | - | cloning artifact |
| Phe 163 | - | cloning artifact |
| Ala 164 | - | cloning artifact |
| Leu 165 | - | cloning artifact |
| Leu 166 | - | cloning artifact |
| Thr 167 | - | cloning artifact |
| Cys 168 | - | cloning artifact |
| Arg 169 | - | cloning artifact |
| Leu 170 | - | cloning artifact |
| Asp 171 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61429.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 372.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 226.3 | |
| All* | Total formula weight | 62028.2 |
