1X27
Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Proto-oncogene tyrosine-protein kinase LCK | polymer | 167 | 18879.0 | 6 | UniProt (P06239) Pfam (PF00018) Pfam (PF00017) | Homo sapiens (human) | P56-LCK, LSK, T cell-specific protein-tyrosine kinase |
| 2 | G, H, I, J, K... (I, J, K, L, M...) | CRK-associated substrate | polymer | 9 | 1265.3 | 6 | UniProt (Q63767) | p130cas, Breast cancer anti-estrogen resistance 1 protein | |
| 3 | M, N, O, P, Q... (A, B, C, D, E...) | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
| 4 | S, T, U, V, W... (A, B, C, D, E...) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 64 - 226 (UniProt: P06239)
I, J, K, L, M, N: 759 - 767 (UniProt: Q63767)
| PDB | External Database | Details |
|---|---|---|
| Gly 60 | - | cloning artifact |
| Ser 61 | - | cloning artifact |
| His 62 | - | cloning artifact |
| Met 63 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Ptr 762 | Tyr 762 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 120865.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 137.9 | |
| All* | Total formula weight | 121003.4 |
