1X27
Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 6 |
| Chain | Residue |
| B | GLU123 |
| B | GLU125 |
| B | PHE128 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA D 10 |
| Chain | Residue |
| D | GLU123 |
| D | GLU125 |
| D | PHE128 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA C 14 |
| Chain | Residue |
| C | GLU123 |
| C | GLU125 |
| C | PHE128 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA F 21 |
| Chain | Residue |
| E | LEU103 |
| E | THR104 |
| F | GLU123 |
| F | GLU125 |
| F | PHE128 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 227 |
| Chain | Residue |
| A | GLU123 |
| A | GLU125 |
| A | PHE128 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA E 227 |
| Chain | Residue |
| E | GLU123 |
| E | GLU125 |
| E | PHE128 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | LEU103 | |
| D | LEU103 | |
| D | PHE163 | |
| D | PRO195 | |
| E | LEU103 | |
| E | PHE163 | |
| E | PRO195 | |
| F | LEU103 | |
| F | PHE163 | |
| F | PRO195 | |
| A | PHE163 | |
| A | PRO195 | |
| B | LEU103 | |
| B | PHE163 | |
| B | PRO195 | |
| C | LEU103 | |
| C | PHE163 | |
| C | PRO195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | ALA160 | |
| B | ALA160 | |
| C | ALA160 | |
| D | ALA160 | |
| E | ALA160 | |
| F | ALA160 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06240 |
| Chain | Residue | Details |
| A | ILE193 | |
| B | ILE193 | |
| C | ILE193 | |
| D | ILE193 | |
| E | ILE193 | |
| F | ILE193 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:38225265 |
| Chain | Residue | Details |
| A | ALA100 | |
| F | ALA100 | |
| B | ALA100 | |
| C | ALA100 | |
| D | ALA100 | |
| E | ALA100 |
