1VZO
The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | RIBOSOMAL PROTEIN S6 KINASE ALPHA 5 | polymer | 355 | 39914.4 | 1 | UniProt (O75582) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | NUCLEAR MITOGEN-AND-STRESS-ACTIVATED KINASE-1, MSK1, RSK-LIKE PROTEIN KINASE, 90 KDA RIBOSOMAL PROTEIN S6 KINASE 5, RLSK |
| 2 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A: -6 - 1 (PDB: 1VZO)
A: 2 - 348 (UniProt: O75582)
| PDB | External Database | Details |
|---|---|---|
| Asp 212 | Ser 212 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39914.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 174.2 | |
| All* | Total formula weight | 40088.6 |
