1VYW

Structure of CDK2/Cyclin A with PNU-292137

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	CELL DIVISION PROTEIN KINASE 2	polymer	309	35251.9	2	UniProt (P24941) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	P33 PROTEIN KINASE
2	B, D (B, D)	CYCLIN A2	polymer	265	30279.0	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	HOMO SAPIENS (HUMAN)	CYCLIN A
3	E, H (A, D)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	F, G (A, C)	N-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)-2-(2-NAPHTHYL)ACETAMIDE	non-polymer		291.3	2	Chemie (292)
5	I, J, K, L (A, B, C, D)	water	water		18.0	410	Chemie (HOH)

Sequence modifications

A, C: -4 - 0 (PDB: 1VYW)
A, C: 299 - 304 (PDB: 1VYW)
A, C: 1 - 298 (UniProt: P24941)
B, D: 168 - 173 (PDB: 1VYW)
B, D: 174 - 432 (UniProt: P20248)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	131061.7
Non-Polymers*	Number of molecules	4
	Total formula weight	774.8
All*	Total formula weight	131836.5

*Water molecules are not included.