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1VSN

Crystal structure of a potent small molecule inhibitor bound to cathepsin K

Replaces:  2FDZ
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ACathepsin Kpolymer21523030.71UniProt (P43235)
Pfam (PF00112)
In PDB
Homo sapiens (human)Cathepsin O, Cathepsin X, Cathepsin O2
2AN-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDEnon-polymer486.61Chemie (NFT)
3waterwater18.0269Chemie (HOH)
Sequence modifications
A: 1 - 211 (UniProt: P43235)
PDBExternal DatabaseDetails
Ile 5Val 119conflict
Ala 41Lys 155conflict
Ala 44Lys 158conflict
Ala 49Ser 163conflict
Arg 77Lys 191conflict
Asp 92Glu 207conflict
Ala 119Lys 233conflict
Ala 127Arg 241conflict
Ala 146Lys 261conflict
Asn 152Ser 268conflict
Ser 154Asn 270conflict
Ala 1156Asn 273conflict
Ala 2168Lys 287conflict
Ser 176Asn 301conflict
Ala 184Lys 305conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight23030.7
Non-Polymers*Number of molecules1
Total formula weight486.6
All*Total formula weight23517.3
*Water molecules are not included.

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PDB entries from 2024-07-24

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