1V7N
Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (L, M, N, O) | Monoclonal TN1 Fab Light Chain | polymer | 213 | 23362.9 | 4 | Mus musculus (house mouse) | ||
| 2 | B, D, F, H (H, I, J, K) | Monoclonal TN1 Fab Heavy Chain | polymer | 217 | 23364.2 | 4 | Mus musculus (house mouse) | ||
| 3 | I, J, K, L (V, X, Y, Z) | Thrombopoietin | polymer | 163 | 17485.5 | 4 | UniProt (P40225) Pfam (PF00758) | Homo sapiens (human) | Megakaryocyte colony stimulating factor, Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, ML, Megakaryocyte growth and development factor, MGDF |
| 4 | M, N, O, P, Q... (L, H, M, I, N...) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
V, X, Y, Z: 1 - 163 (UniProt: P40225)
| PDB | External Database | Details |
|---|---|---|
| Arg 115 | Gln 136 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 256850.3 | |
| All* | Total formula weight | 256850.3 |
