1UVQ

Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN	polymer	197	22275.8	1	UniProt (P01907) Pfam (PF00993) Pfam (PF07654) UniProt (by SIFTS) (E9PMV2) In PDB	HOMO SAPIENS (HUMAN)	QA1*0602, DQ(5) ALPHA CHAIN, DC-1 ALPHA CHAIN
2	B	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN	polymer	198	23029.7	1	UniProt (P03992) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01920) In PDB	HOMO SAPIENS (HUMAN)	DQB1*0602, DQB1*0602 BETA CHAIN, DQ(5), DC-1
3	C	OREXIN	polymer	33	3104.4	1	UniProt (O43612) In PDB	HOMO SAPIENS (HUMAN)	HCRT, HYPOCRETIN-1, HCRT1, OREXIN-B, HYPOCRETIN-2, HCRT2
4	D	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G32152BH)
5	A	GLYCINE	non-polymer		75.1	1	Chemie (GLY)
6	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	B	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
8	B	ACETIC ACID	non-polymer		60.1	1	Chemie (ACY)
9		water	water		18.0	371	Chemie (HOH)

Sequence modifications

A: 1 - 196 (UniProt: P01907)
A: 197 - 197 (PDB: 1UVQ)
B: 3 - 198 (UniProt: P03992)
B: 199 - 200 (PDB: 1UVQ)
C: -4 - 0 (PDB: 1UVQ)
C: 13 - 28 (PDB: 1UVQ)
C: 1 - 12 (UniProt: O43612)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	48409.9
Branched	Number of molecules	1
	Total formula weight	732.7
Non-Polymers*	Number of molecules	5
	Total formula weight	642.9
All*	Total formula weight	49785.5

*Water molecules are not included.