1UEA
MMP-3/TIMP-1 COMPLEX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | MATRIX METALLOPROTEINASE-3 | polymer | 173 | 19510.3 | 2 | UniProt (P08254) Pfam (PF00413) | Homo sapiens (human) | MMP-3 IS IDENTICAL WITH STROMELYSIN 1 |
| 2 | B, D (B, D) | TISSUE INHIBITOR OF METALLOPROTEINASE-1 | polymer | 184 | 20646.8 | 2 | UniProt (P01033) Pfam (PF00965) | Homo sapiens (human) | TIMP-1 |
| 3 | E, F, J, K (A, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G, H, I, L, M... (A, C) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 511 | Chemie (HOH) |
Sequence modifications
A, C: 83 - 255 (UniProt: P08254)
B, D: 1 - 184 (UniProt: P01033)
| PDB | External Database | Details |
|---|---|---|
| Mse 143 | Met 160 | engineered mutation |
| Mse 219 | Met 236 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 30 | Asn 53 | engineered mutation |
| Ala 78 | Asn 101 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 80314.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 502.1 | |
| All* | Total formula weight | 80816.3 |
