1U0H
STRUCTURAL BASIS FOR THE INHIBITION OF MAMMALIAN ADENYLYL CYCLASE BY MANT-GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Adenylate cyclase, type V | polymer | 225 | 25526.5 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus familiaris (dog) | ATP pyrophosphate-lyase, Ca2+, -inhibitable adenylyl cyclase |
| 2 | B (B) | Adenylate cyclase, type II | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (Norway rat) | ATP pyrophosphate-lyase, Adenylyl cyclase |
| 3 | C (C) | Guanine nucleotide-binding protein G(s), alpha subunit | polymer | 394 | 45769.5 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (cattle) | Adenylate cyclase-stimulating G alpha protein |
| 4 | D, E, H (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | F (A) | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) | |||
| 6 | G (A) | 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 656.3 | 1 | Chemie (ONM) | |||
| 7 | I (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | J (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 9 | K, L, M (A, B, C) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 361 - 580 (UniProt: P30803)
| PDB | External Database | Details |
|---|---|---|
| Met 356 | - | initiating methionine |
| His 357 | - | expression tag |
| His 358 | - | expression tag |
| His 359 | - | expression tag |
| His 360 | - | expression tag |
| His 362 | Val 443 | conflict |
| Met 476 | Val 557 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 95013.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1714.4 | |
| All* | Total formula weight | 96727.5 |
