1TYE
Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Integrin alpha-IIb | polymer | 452 | 49044.4 | 3 | UniProt (P08514) Pfam (PF01839) | Homo sapiens (human) | Platelet membrane glycoprotein IIb; GPalpha IIb; GPIIb; CD41 antigen |
| 2 | B, D, F (B, D, F) | Integrin beta-3 | polymer | 440 | 48719.2 | 3 | UniProt (P05106) Pfam (PF17205) Pfam (PF00362) | Homo sapiens (human) | Platelet membrane glycoprotein IIIa; GPIIIa; CD61 antigen |
| 3 | G, I (G, I) | beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G24199JF) | |||
| 4 | H (H) | beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G66753FB) | |||
| 5 | BA, CA, EA, FA, GA... (D, E, A, F, B...) | CALCIUM ION | non-polymer | 40.1 | 18 | Chemie (CA) | |||
| 6 | DA, IA, JA, N, O... (E, F, B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 7 | KA, P, Z (F, B, D) | CACODYLATE ION | non-polymer | 137.0 | 3 | Chemie (CAC) | |||
| 8 | AA, LA, Q (D, F, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 9 | OA, PA, QA, RA, SA... (A, B, C, D, E...) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 293290.9 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2408.2 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 2753.7 | |
| All* | Total formula weight | 298452.8 |
