1TYE
Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | SER121 | |
| A | ASP305 | |
| A | ASP365 | |
| A | ASP367 | |
| A | ASP369 | |
| A | TYR371 | |
| A | ASP373 | |
| A | ASP426 | |
| A | ASP428 | |
| A | ASN430 | |
| A | TYR432 | |
| B | GLU220 | |
| A | ASP434 | |
| C | GLU243 | |
| C | ASP245 | |
| C | ASP247 | |
| C | THR250 | |
| C | GLU252 | |
| C | ASP297 | |
| C | ASN299 | |
| C | ASP301 | |
| C | ARG303 | |
| D | SER121 | |
| C | ASP305 | |
| C | ASP365 | |
| C | ASP367 | |
| C | ASP369 | |
| C | TYR371 | |
| C | ASP373 | |
| C | ASP426 | |
| C | ASP428 | |
| C | ASN430 | |
| C | TYR432 | |
| D | GLU220 | |
| C | ASP434 | |
| E | GLU243 | |
| E | ASP245 | |
| E | ASP247 | |
| E | THR250 | |
| E | GLU252 | |
| E | ASP297 | |
| E | ASN299 | |
| E | ASP301 | |
| E | ARG303 | |
| F | SER121 | |
| E | ASP305 | |
| E | ASP365 | |
| E | ASP367 | |
| E | ASP369 | |
| E | TYR371 | |
| E | ASP373 | |
| E | ASP426 | |
| E | ASP428 | |
| E | ASN430 | |
| E | TYR432 | |
| F | GLU220 | |
| E | ASP434 | |
| A | ASN299 | |
| A | ASP301 | |
| A | ARG303 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | SER123 | |
| D | SER123 | |
| F | SER123 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASP126 | |
| B | ASP127 | |
| D | ASP126 | |
| D | ASP127 | |
| F | ASP126 | |
| F | ASP127 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | ASP158 | |
| F | ASN215 | |
| F | ASP217 | |
| F | PRO219 | |
| B | ASN215 | |
| B | ASP217 | |
| B | PRO219 | |
| D | ASP158 | |
| D | ASN215 | |
| D | ASP217 | |
| D | PRO219 | |
| F | ASP158 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: in LIMBS binding site => ECO:0007744|PDB:4G1M |
| Chain | Residue | Details |
| B | ASP251 | |
| D | ASP251 | |
| F | ASP251 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | MET335 | |
| D | MET335 | |
| F | MET335 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN99 | |
| D | ASN99 | |
| F | ASN99 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN320 | |
| B | ASN371 | |
| D | ASN320 | |
| D | ASN371 | |
| F | ASN320 | |
| F | ASN371 |
