1TW7
Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protease | polymer | 99 | 10739.6 | 2 | GenBank (30142908) Pfam (PF00077) UniProt (by SIFTS) (Q5RTL1) | Human immunodeficiency virus 1 | |
| 2 | C, D (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 380 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (GenBank: 30142908)
| PDB | External Database | Details |
|---|---|---|
| Ile 10 | Leu 10 | engineered mutation |
| Asn 25 | Asp 25 | engineered mutation |
| Val 36 | Met 36 | engineered mutation |
| Leu 46 | Met 46 | engineered mutation |
| Val 54 | Ile 54 | engineered mutation |
| Val 62 | Ile 62 | engineered mutation |
| Pro 63 | Leu 63 | engineered mutation |
| Val 71 | Ala 71 | engineered mutation |
| Ala 82 | Val 82 | engineered mutation |
| Val 84 | Ile 84 | engineered mutation |
| Met 90 | Leu 90 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21479.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 46.0 | |
| All* | Total formula weight | 21525.2 |
