1TVK
The binding mode of epothilone A on a,b-tubulin by electron crystallography
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tubulin alpha chain | polymer | 440 | 48869.1 | 1 | UniProt (P02550) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q2HJ86) | Bos taurus (cattle) | |
| 2 | B (B) | Tubulin beta chain | polymer | 427 | 47940.9 | 1 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q6B856) | Bos taurus (cattle) | |
| 3 | C (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 4 | D (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 5 | E (B) | EPOTHILONE A | non-polymer | 493.7 | 1 | Chemie (EP) |
Sequence modifications
A: 1 - 440 (UniProt: P02550)
| PDB | External Database | Details |
|---|---|---|
| Gly 265 | Ala 265 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96810.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1460.0 | |
| All* | Total formula weight | 98270.1 |
