1TVK
The binding mode of epothilone A on a,b-tubulin by electron crystallography
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tubulin alpha chain | polymer | 440 | 48869.1 | 1 | UniProt (P02550) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q2HJ86) | Bos taurus (cattle) | |
| 2 | B (B) | Tubulin beta chain | polymer | 427 | 47940.9 | 1 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q6B856) | Bos taurus (cattle) | |
| 3 | C (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 4 | D (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 5 | E (B) | EPOTHILONE A | non-polymer | 493.7 | 1 | Chemie (EP) PubChem (21863024) PubChem (177385288) PubChem (177482479) PubChem (177594643) PubChem (177603401) PubChem (16760414) PubChem (388944) PubChem (45489244) PubChem (49852287) PubChem (52949056) PubChem (58719462) PubChem (59013104) PubChem (59014876) PubChem (59161915) PubChem (53873401) PubChem (59628535) PubChem (59628539) PubChem (59648958) PubChem (59894005) PubChem (59949922) PubChem (60010194) PubChem (59628540) PubChem (71431401) PubChem (177486551) PubChem (177548259) PubChem (73106690) PubChem (73265380) PubChem (88566410) PubChem (88881421) PubChem (88881427) PubChem (89218245) PubChem (89312910) PubChem (89321857) PubChem (90712719) PubChem (90718436) PubChem (90784257) PubChem (9848560) PubChem (91024640) PubChem (91090689) PubChem (91169037) PubChem (91197558) PubChem (91307275) PubChem (91339047) PubChem (91346622) PubChem (91437365) PubChem (91614546) PubChem (448799) PubChem (10553224) PubChem (10838895) PubChem (10973050) PubChem (91036120) PubChem (91607447) PubChem (15280961) PubChem (15280962) PubChem (15280963) PubChem (15280965) PubChem (124413514) PubChem (10458410) PubChem (117841728) PubChem (11179426) PubChem (118213856) PubChem (12047293) PubChem (123280763) PubChem (123979299) PubChem (124404415) PubChem (124635553) PubChem (126969095) PubChem (129010102) PubChem (139024640) PubChem (138106946) PubChem (138115002) PubChem (143590706) PubChem (143590714) PubChem (145856632) PubChem (158457124) PubChem (166639477) PubChem (169452172) PubChem (171149197) PubChem (171319510) |
Sequence modifications
A: 1 - 440 (UniProt: P02550)
| PDB | External Database | Details |
|---|---|---|
| Gly 265 | Ala 265 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96810.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1460.0 | |
| All* | Total formula weight | 98270.1 |
