1TOG

Hydrocinnamic acid-bound structure of SRHEPT + A293D mutant of E. coli aspartate aminotransferase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Aspartate aminotransferase	polymer	396	43869.3	2	UniProt (P00509) Pfam (PF00155) In PDB	Escherichia coli	Transaminase A, ASPAT
2	A, B	HYDROCINNAMIC ACID	non-polymer		150.2	2	Chemie (HCI)
3		water	water		18.0	137	Chemie (HOH)

Sequence modifications

A, B: 5 - 400 (UniProt: P00509)

PDB	External Database	Details
Thr 12	Ala 8	engineered mutation
Thr 13	Pro 9	engineered mutation
Asp 34	Asn 30	engineered mutation
Ser 109	Thr 104	engineered mutation
Llp 258	Lys 246	modified residue
Ala 261	Gly 249	engineered mutation
Gly 285	Ser 273	engineered mutation
Asp 293	Ala 281	engineered mutation
Ser 297	Asn 285	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87738.6
Non-Polymers*	Number of molecules	2
	Total formula weight	300.3
All*	Total formula weight	88038.9

*Water molecules are not included.