1TB7

Catalytic Domain Of Human Phosphodiesterase 4D In Complex With AMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	332	38207.3	2	UniProt (Q08499) Pfam (PF00233)	Homo sapiens (human)	DPDE3, PDE43
2	C, U (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, V (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG) PubChem (888)
4	E, W (A, B)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (34768) PubChem (83862) PubChem (40467049) PubChem (40469468) PubChem (446048) PubChem (44348067) PubChem (45358029) PubChem (40459109) PubChem (515384) PubChem (46874558) PubChem (638042) PubChem (46875232) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (5316444) PubChem (5742864) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (12163610) PubChem (12358355) PubChem (92144436) PubChem (122197642) PubChem (12358354) PubChem (162290139) PubChem (162946266) PubChem (171699505)
5	AA, BA, CA, DA, EA... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	27	Chemie (EDO)
6	T (A)	2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		282.3	1	Chemie (B3P) PubChem (125132)
7	KA, LA (A, B)	water	water		18.0	359	Chemie (HOH)

Sequence modifications

A, B: 86 - 413 (UniProt: Q08499)

PDB	External Database	Details
Gly 82	-	expression tag
Ser 83	-	expression tag
His 84	-	expression tag
Met 85	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76414.5
Non-Polymers*	Number of molecules	34
	Total formula weight	2832.0
All*	Total formula weight	79246.6

*Water molecules are not included.