Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
A | 0007165 | biological_process | signal transduction |
A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
B | 0007165 | biological_process | signal transduction |
B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE ZN A 1001 |
Chain | Residue |
A | HIS164 |
A | HIS200 |
A | ASP201 |
A | ASP318 |
A | MG1002 |
A | AMP1003 |
A | HOH1190 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG A 1002 |
Chain | Residue |
A | AMP1003 |
A | HOH1187 |
A | HOH1188 |
A | HOH1189 |
A | HOH1190 |
A | ASP201 |
A | ZN1001 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE ZN B 1001 |
Chain | Residue |
B | HIS164 |
B | HIS200 |
B | ASP201 |
B | ASP318 |
B | MG1002 |
B | AMP1003 |
B | HOH1175 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG B 1002 |
Chain | Residue |
B | ASP201 |
B | ZN1001 |
B | AMP1003 |
B | HOH1172 |
B | HOH1173 |
B | HOH1174 |
B | HOH1175 |
site_id | AC5 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE AMP B 1003 |
Chain | Residue |
B | HIS160 |
B | HIS164 |
B | ASP201 |
B | ASP318 |
B | LEU319 |
B | ASN321 |
B | GLN369 |
B | PHE372 |
B | EDO543 |
B | ZN1001 |
B | MG1002 |
B | HOH1004 |
B | HOH1027 |
B | HOH1104 |
B | HOH1174 |
B | HOH1175 |
site_id | AC6 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE AMP A 1003 |
Chain | Residue |
A | HIS160 |
A | HIS164 |
A | ASP201 |
A | ASP318 |
A | LEU319 |
A | ASN321 |
A | GLN369 |
A | PHE372 |
A | EDO523 |
A | ZN1001 |
A | MG1002 |
A | HOH1005 |
A | HOH1053 |
A | HOH1057 |
A | HOH1105 |
A | HOH1187 |
A | HOH1189 |
A | HOH1190 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 501 |
Chain | Residue |
B | GLU366 |
B | EDO503 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 502 |
Chain | Residue |
A | LYS262 |
A | ILE265 |
A | ASP266 |
A | HOH1021 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 503 |
Chain | Residue |
B | ARG330 |
B | THR333 |
B | ASP334 |
B | TYR406 |
B | EDO501 |
B | HOH1165 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 508 |
Chain | Residue |
B | SER208 |
B | PHE340 |
B | PRO356 |
B | HOH1059 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 509 |
Chain | Residue |
B | SER259 |
B | HOH1056 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 515 |
Chain | Residue |
A | ASN115 |
A | ALA155 |
A | ASN162 |
A | HOH1064 |
A | HOH1103 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 516 |
Chain | Residue |
A | THR178 |
A | TRP384 |
A | VAL388 |
A | ASP391 |
A | ALA392 |
A | ILE395 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 517 |
Chain | Residue |
B | PHE238 |
B | ARG257 |
B | ARG261 |
B | HOH1084 |
B | HOH1093 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 519 |
Chain | Residue |
A | ALA183 |
A | VAL184 |
A | PHE185 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 520 |
Chain | Residue |
A | ARG257 |
A | ARG261 |
A | HOH1146 |
site_id | BC8 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE EDO A 521 |
Chain | Residue |
A | HIS160 |
A | GLY206 |
A | VAL207 |
A | SER208 |
A | GLU339 |
A | PHE340 |
A | GLN343 |
A | EDO522 |
A | HOH1057 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 522 |
Chain | Residue |
A | SER208 |
A | PRO356 |
A | CYS358 |
A | EDO521 |
site_id | CC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE EDO A 523 |
Chain | Residue |
A | ASN209 |
A | LEU229 |
A | GLU230 |
A | ASP272 |
A | MET273 |
A | AMP1003 |
A | HOH1053 |
A | HOH1056 |
A | HOH1137 |
A | HOH1187 |
site_id | CC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 524 |
Chain | Residue |
A | HOH1032 |
B | GLU218 |
site_id | CC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 525 |
Chain | Residue |
A | ASN224 |
B | LYS262 |
B | ILE265 |
B | ASP266 |
B | HOH1011 |
B | HOH1087 |
site_id | CC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 526 |
Chain | Residue |
A | GLN407 |
B | GLU150 |
B | ASP151 |
B | TYR153 |
B | ASN162 |
B | EDO534 |
B | HOH1075 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 533 |
Chain | Residue |
A | HIS154 |
A | ASP203 |
A | PRO205 |
A | LEU219 |
site_id | CC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 534 |
Chain | Residue |
B | ASN115 |
B | ALA155 |
B | ASN162 |
B | ILE163 |
B | EDO526 |
B | HOH1075 |
B | HOH1164 |
site_id | CC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 535 |
Chain | Residue |
B | ASN209 |
B | GLU230 |
B | MET273 |
B | EDO543 |
B | HOH1027 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 536 |
Chain | Residue |
A | ARG330 |
A | GLU366 |
A | TRP405 |
A | TYR406 |
A | HOH1088 |
B | PRO411 |
site_id | CC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 537 |
Chain | Residue |
A | PRO325 |
A | GLN327 |
A | HOH1055 |
B | TRP405 |
B | HOH1076 |
site_id | DC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 538 |
Chain | Residue |
A | THR186 |
A | LEU188 |
A | GLU189 |
A | SER259 |
A | MET263 |
A | HOH1120 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 539 |
Chain | Residue |
A | ARG116 |
A | MET147 |
A | THR148 |
A | ASP151 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 540 |
Chain | Residue |
A | ASP334 |
A | MET337 |
A | GLU338 |
A | PHE341 |
A | HOH1111 |
site_id | DC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 541 |
Chain | Residue |
B | ASP266 |
B | ILE307 |
B | GLN311 |
B | EDO542 |
B | HOH1106 |
site_id | DC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 542 |
Chain | Residue |
B | ASP266 |
B | LEU269 |
B | LYS275 |
B | GLN311 |
B | EDO541 |
site_id | DC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE EDO B 543 |
Chain | Residue |
B | HIS160 |
B | HIS204 |
B | GLY206 |
B | VAL207 |
B | SER208 |
B | GLU339 |
B | EDO535 |
B | AMP1003 |
B | HOH1027 |
B | HOH1059 |
site_id | DC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE B3P A 601 |
Chain | Residue |
A | LYS94 |
A | GLU95 |
A | GLU97 |
A | ASP98 |
A | HIS105 |
A | ARG108 |
A | HOH1147 |
B | ASP394 |
B | ASP397 |
B | ASP401 |
B | HOH1123 |
Functional Information from PROSITE/UniProt
site_id | PS00126 |
Number of Residues | 12 |
Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
Chain | Residue | Details |
A | HIS200-PHE211 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | HIS160 | |
B | HIS160 | |
Chain | Residue | Details |
A | HIS160 | |
A | ASN321 | |
A | GLN369 | |
B | HIS160 | |
B | ASN321 | |
B | GLN369 | |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
Chain | Residue | Details |
A | HIS164 | |
B | HIS164 | |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
Chain | Residue | Details |
A | HIS200 | |
A | ASP318 | |
B | HIS200 | |
B | ASP318 | |
Chain | Residue | Details |
A | ASP201 | |
A | PHE372 | |
B | ASP201 | |
B | PHE372 | |