1T8U
Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP and tetrasaccharide substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 | polymer | 272 | 31128.9 | 2 | GenBank (5174465) Pfam (PF00685) UniProt (by SIFTS) (Q9Y663) | Homo sapiens (human) | HEPARIN-GLUCOSAMINE 3-O-SULFOTRANSFERASE, 3-OST-3 |
| 2 | C (C) | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | branched | 1154.9 | 1 | In PDB GlyTouCan (G88016IC) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E, F (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | G, H (B) | ADENOSINE-3'-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (A3P) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 358 | Chemie (HOH) |
Sequence modifications
A, B: 139 - 406 (GenBank: 5174465)
| PDB | External Database | Details |
|---|---|---|
| Gly 135 | - | cloning artifact |
| Pro 136 | - | cloning artifact |
| Asn 137 | - | cloning artifact |
| Ser 138 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62257.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1154.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 996.4 | |
| All* | Total formula weight | 64409.2 |
