1T64
Crystal Structure of human HDAC8 complexed with Trichostatin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone deacetylase 8 | polymer | 377 | 41802.5 | 2 | UniProt (Q9BY41) Pfam (PF00850) | Homo sapiens (human) | HDAC8 |
| 2 | C, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, K, L (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 4 | F, G, M, N (A, B) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 5 | H, I, O, P (A, B) | TRICHOSTATIN A | non-polymer | 302.4 | 4 | Chemie (TSN) | |||
| 6 | Q, R (A, B) | water | water | 18.0 | 684 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 377 (UniProt: Q9BY41)
| PDB | External Database | Details |
|---|---|---|
| Leu 31 | Pro 31 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83605.0 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1592.6 | |
| All* | Total formula weight | 85197.5 |
