1T2K
Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | 31-MER | polymer | 31 | 9724.3 | 1 | |||
| 2 | B (F) | 31-MER | polymer | 31 | 9336.0 | 1 | |||
| 3 | C, D (A, B) | Interferon regulatory factor 3 | polymer | 112 | 13058.8 | 2 | UniProt (Q14653) Pfam (PF00605) | Homo sapiens (human) | IRF-3 |
| 4 | E (C) | Transcription factor AP-1 | polymer | 62 | 7314.7 | 1 | UniProt (P05412) Pfam (PF00170) | Homo sapiens (human) | |
| 5 | F (D) | Cyclic-AMP-dependent transcription factor ATF-2 | polymer | 61 | 7133.3 | 1 | UniProt (P15336) Pfam (PF00170) | Homo sapiens (human) | Activating transcription factor 2, cAMP response element binding protein CRE- BP1, HB16 |
| 6 | G, H, I (E, F, A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
C: 253 - 314 (UniProt: P05412)
D: 336 - 396 (UniProt: P15336)
| PDB | External Database | Details |
|---|---|---|
| Met 253 | Ile 253 | cloning artifact |
| Ser 269 | Cys 269 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 351 | Cys 351 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 59626.0 | |
| All* | Total formula weight | 59626.0 |
