1T2K
Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PROSITE/UniProt
| site_id | PS00036 |
| Number of Residues | 16 |
| Details | BZIP_BASIC Basic-leucine zipper (bZIP) domain signature. KfleRNRaAASRsRQK |
| Chain | Residue | Details |
| D | LYS339-LYS354 | |
| C | ARG257-ARG272 |
| site_id | PS00601 |
| Number of Residues | 33 |
| Details | IRF_1 IRF tryptophan pentad repeat DNA-binding domain signature. WvNksrtrFrIPWkHglrqdaqqe.DfgIFQaWA |
| Chain | Residue | Details |
| A | TRP26-ALA58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCA and PKC/PRKCB => ECO:0000269|PubMed:19176525 |
| Chain | Residue | Details |
| D | PHE340 | |
| D | GLU367 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17590016 |
| Chain | Residue | Details |
| D | VAL357 | |
| D | GLY374 | |
| B | THR3 | |
| B | THR75 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PAK2 => ECO:0000269|PubMed:21177766 |
| Chain | Residue | Details |
| C | THR286 | |
| A | SER97 | |
| B | SER14 | |
| B | SER97 |
