1T1F
Crystal Structure of Native Antithrombin in its Monomeric Form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Antithrombin-III | polymer | 432 | 49091.1 | 3 | UniProt (P01008) Pfam (PF00079) | Homo sapiens (human) | ATIII; PRO0309 |
| 2 | D, F, G, I, J... (D, F, G, I, J...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 3 | E, H, K (E, H, K) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 4 | AA, CA, DA, EA, FA... (B, C, A) | IODIDE ION | non-polymer | 126.9 | 21 | Chemie (IOD) | |||
| 5 | BA, JA, T (B, C, A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | KA, LA, MA (A, B, C) | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 432 (UniProt: P01008)
| PDB | External Database | Details |
|---|---|---|
| Ala 137 | Ser 169 | engineered mutation |
| Cys 317 | Val 349 | engineered mutation |
| Cys 401 | Thr 433 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 147273.2 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 4306.0 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2941.3 | |
| All* | Total formula weight | 154520.5 |
