1SYK

Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP-dependent protein kinase, alpha-catalytic subunit	polymer	350	40656.3	2	UniProt (P05132) Pfam (PF00069)	Mus musculus (house mouse)	PKA C-alpha
2	C, D (A, B)	water	water		18.0	113	Chemie (HOH)

Sequence modifications

A, B: 1 - 350 (UniProt: P05132)

PDB	External Database	Details
Tpo 197	Thr 197	modified residue
Gln 230	Glu 230	engineered mutation
Sep 338	Ser 338	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	81312.7
All*	Total formula weight	81312.7

*Water molecules are not included.