1SUQ

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R185545

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	REVERSE TRANSCRIPTASE	polymer	560	64501.0	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus 1	HIV-1 RT
2	B	REVERSE TRANSCRIPTASE	polymer	430	50281.8	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus 1	HIV-1 RT
3	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	A	(6-[4-(AMINOMETHYL)-2,6-DIMETHYLPHENOXY]-2-{[4-(AMINOMETHYL)PHENYL]AMINO}-5-BROMOPYRIMIDIN-4-YL)METHANOL	non-polymer		450.3	1	Chemie (185)

Sequence modifications

A: 1 - 560 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 447	engineered mutation

B: 1 - 430 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 447	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	114782.7
Non-Polymers*	Number of molecules	2
	Total formula weight	474.6
All*	Total formula weight	115257.3

*Water molecules are not included.