1SL3
crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | thrombin | polymer | 287 | 33080.0 | 1 | UniProt (P00734) Pfam (PF09396) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (B) | Hirudin | polymer | 11 | 1434.5 | 1 | UniProt (P28504) | Hirudo medicinalis | |
| 3 | C (A) | (2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-YL)ETHYL]AMINO}-2-OXOPYRAZIN-1(2H)-YL]-N-[5-CHLORO-2-(1H-TETRAZOL-1-YL)BENZYL]ACETAMIDE | non-polymer | 552.3 | 1 | Chemie (170) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
B: 355 - 364 (UniProt: P28504)
| PDB | External Database | Details |
|---|---|---|
| Ala 365 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34514.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 552.3 | |
| All* | Total formula weight | 35066.8 |
