Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 170 A 1001 |
| Chain | Residue |
| A | HIS57 |
| A | SER195 |
| A | VAL213 |
| A | SER214 |
| A | TRP215 |
| A | GLY216 |
| A | GLU217 |
| A | GLY219 |
| A | CYS220 |
| A | GLY226 |
| A | PHE227 |
| A | TYR60 |
| A | HOH1099 |
| A | HOH1103 |
| A | HOH1129 |
| A | TRP60 |
| A | GLU97 |
| A | ILE174 |
| A | ASP189 |
| A | ALA190 |
| A | CYS191 |
| A | GLU192 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN B OF HIRUDIN |
| Chain | Residue |
| A | PHE34 |
| A | GLN38 |
| A | GLU39 |
| A | LEU40 |
| A | LEU65 |
| A | ARG73 |
| A | THR74 |
| A | ARG75 |
| A | TYR76 |
| A | LYS81 |
| A | ILE82 |
| A | HOH1036 |
| B | HOH69 |
| B | HOH86 |
| B | HOH88 |
| B | HOH142 |
| B | ALA365 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| A | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000250 |
| Chain | Residue | Details |
| B | TYS363 | |
| A | ASP102 | |
| A | SER195 | |
| Chain | Residue | Details |
| A | ARG15 | |
| Chain | Residue | Details |
| A | ASN60 | |
