1SHY

The Crystal Structure of HGF beta-chain in Complex with the Sema Domain of the Met Receptor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatocyte growth factor	polymer	234	26014.1	1	UniProt (P14210) Pfam (PF00089) In PDB	Homo sapiens (human)	Scatter factor, SF, Hepatopoeitin A
2	B	Hepatocyte growth factor receptor	polymer	551	62535.9	1	UniProt (P08581) Pfam (PF01403) Pfam (PF01437) In PDB	Homo sapiens (human)	Met proto-oncogene tyrosine kinase, c-met, HGF receptor, HGF-SF receptor

Sequence modifications

A: 495 - 728 (UniProt: P14210)

PDB	External Database	Details
Ser 604	Cys 604	engineered mutation

B: 25 - 567 (UniProt: P08581)

PDB	External Database	Details
Leu 303	Lys 303	SEE REMARK 999
Val 304	Arg 304	SEE REMARK 999
Pro 305	Lys 305	SEE REMARK 999
Arg 306	Lys 306	SEE REMARK 999
Gly 307	Arg 307	SEE REMARK 999
His 568	-	expression tag
His 569	-	expression tag
His 570	-	expression tag
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	88550.0
All*	Total formula weight	88550.0

*Water molecules are not included.