1SEU

Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3'	polymer	10	3061.1	1
2	C	5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'	polymer	12	3716.5	1
3	D	5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'	polymer	22	6690.4	1
4	A	DNA topoisomerase I	polymer	592	70221.0	1	UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) In PDB	Homo sapiens (human)
5	D	2,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE	non-polymer		519.5	1	Chemie (SA3)

Sequence modifications

A: 174 - 765 (UniProt: P11387)

PDB	External Database	Details
Ser 722	Asn 722	engineered mutation
Ptr 723	Tyr 723	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	83688.9
Non-Polymers*	Number of molecules	1
	Total formula weight	519.5
All*	Total formula weight	84208.4

*Water molecules are not included.