1SC6

Crystal Structure of W139G D-3-Phosphoglycerate dehydrogenase complexed with NAD+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	D-3-phosphoglycerate dehydrogenase	polymer	404	43713.6	4	UniProt (P0A9T0) Pfam (PF00389) Pfam (PF02826) Pfam (PF01842) In PDB	Escherichia coli	PGDH
2	A, B, C, D	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
3		water	water		18.0	463	Chemie (HOH)

Sequence modifications

A, B, C, D: 7 - 410 (UniProt: P0A9T0)

PDB	External Database	Details
Ala 81	Cys 80	engineered mutation
Ala 83	Cys 82	engineered mutation
Gly 139	Trp 138	engineered mutation
Mse 175	Met 174	modified residue
Mse 203	Met 202	modified residue
Mse 220	Met 219	modified residue
Mse 221	Met 220	modified residue
Mse 229	Met 228	modified residue
Ala 250	Cys 249	engineered mutation
Ala 282	Cys 281	engineered mutation
Mse 341	Met 340	modified residue
Mse 376	Met 375	modified residue
Mse 397	Met 396	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	174854.2
Non-Polymers*	Number of molecules	4
	Total formula weight	2653.7
All*	Total formula weight	177507.9

*Water molecules are not included.