1SA1

Tubulin-podophyllotoxin: stathmin-like domain complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Tubulin alpha chain	polymer	451	50163.3	2	UniProt (P02550) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q2HJ86) In PDB	Bos taurus (cattle)
2	B, D	Tubulin beta chain	polymer	445	49907.8	2	UniProt (P02554) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q6B856) In PDB	Bos taurus (cattle)
3	E	Stathmin 4	polymer	142	16713.0	1	UniProt (P02554) Pfam (PF00836) UniProt (by SIFTS) (P63043) In PDB	Rattus norvegicus (Norway rat)	Stathmin-like protein B3, RB3
4	A, C	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	A, C	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	B, D	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
7	B, D	9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE	non-polymer		414.4	2	Chemie (POD)

Sequence modifications

A, C: 1 - 451 (UniProt: P02550)

PDB	External Database	Details
Ile 265	Ala 265	SEE REMARK 999

E: 5 - 145 (UniProt: P02554)

PDB	External Database	Details
Ala 4	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	216855.2
Non-Polymers*	Number of molecules	8
	Total formula weight	2810.2
All*	Total formula weight	219665.4

*Water molecules are not included.