1RO9
CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-Br-AMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 378 | 43451.9 | 2 | UniProt (Q07343) Pfam (PF00233) | Homo sapiens (human) | DPDE4, PDE32 |
| 2 | C, D, F, G (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, H (A, B) | 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE | non-polymer | 426.1 | 2 | Chemie (8BR) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 263 | Chemie (HOH) |
Sequence modifications
A, B: 152 - 528 (UniProt: Q07343)
| PDB | External Database | Details |
|---|---|---|
| Met 151 | - | initiating methionine |
| Ala 487 | Ser 659 | engineered mutation |
| Ala 489 | Ser 661 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86903.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1113.9 | |
| All* | Total formula weight | 88017.6 |
